Precancerous lesions of the gastrointestinal tract
نویسندگان
چکیده
منابع مشابه
Precancerous lesions of the gastrointestinal tract.
In the large intestine, the pathologist has to differentiate between multiple polyps and polyposis (more than 100 polyps), further between adenomatosis (coli) and non-neoplastic (tumorlike) polyposis. Without prophylactic colectomy, in about 80% of adenomatosis patients an evolution of cancer is observed. Patients with extensive or total ulcerative colitis and a long history have an increased r...
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PURPOSE It is important to identify the definitive molecular switches involved in the malignant transformation of premalignant tissues. Cellular senescence is a specific characteristic of precancerous tissues, but not of cancers, which might reflect tumorigenesis-protecting mechanisms in premalignant lesions. Polycomb protein Bmi1, which is a potent negative regulator of the p16INK4 gene, suppr...
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Upper gastrointestinal tract cancers are one of the most important leading causes of cancer death worldwide. Diagnosis at late stages always brings about poor outcome of these malignancies. The early detection of precancerous or early cancerous lesions of gastrointestinal tract is therefore of utmost importance to improve the overall outcome and maintain a good quality of life of patients. The ...
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This study is based on the clinical records and post-mortem findings of 264 patients with leukaemia. Gross leukaemic lesions in the gastrointestinal tract were found in 39 patients, an overall incidence of 14.8%. The incidence in all types of acute leukaemia was 18.4%, in chronic leukaemias 9.6%, and in myeloid leukaemia 10.9%. The ileum, stomach, and proximal colon were the sites most commonly...
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ژورنال
عنوان ژورنال: Gut
سال: 1986
ISSN: 0017-5749
DOI: 10.1136/gut.27.1.116